Month: August 2017

A small-molecule drug inhibitor called vismodegib successfully treated a dire case of infiltrative basal cell carcinoma. According to the authors, this case qualifies as a first to report a complete remission for this subset of skin cancer.   Basal cell carcinoma (BCC) is one of the most common types of skin cancer. For patients with
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Commonly used for treating acid reflux and stomach ulcers, proton pump inhibitors (PPIs)have recently been questioned as to whether these drugs are also increasing the risk of patients developing dementia and Alzheimer’s Disease (AD).  A recent study aimed to further investigate this associated risk and whether the use of PPIs could indeed lead to mild
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A meta-analysis combining results across studies assessed outcomes of tight versus standard glucose management on the prevention of onset and progression of end-stage kidney disease (ESKD) in diabetic patients. Study results suggest that diabetic patients who were under stringent glucose control have a comparable risk of kidney failure to those under standard glucose management.  
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  Human papillomavirus (HPV) is responsible for causing cervical cancer in many women worldwide, and successful screening programs have been accredited with helping to increase the capacity to identify and treat precancerous and pre-invasive disease. Quantitative methylation of the POU4F3 gene biomarker is a valuable tool for high-grade CIN detection.   Cervical cancer, caused by the human
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  Chronic kidney disease is both a cause and consequence of hypertension. In patients with both conditions, accurate evaluation and a tailored treatment program are essential for successful hypertension management.     Blood circulates through the body at a certain pressure within the arteries. This pressure changes depending on activity levels– elevating during exercise, to
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A chronic inflammatory disease of the airways, asthma affects approximately 315 million people worldwide. With 5 – 10% (≈15 – 31.5 million) of these people suffering from severe asthma, research into treatments for the disease is ongoing. A study recently looked at an alternative treatment to help manage severe asthma in patients relying upon oral
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Stress urinary incontinence, a condition in which individuals experience incontinence during physical exertion, could affect up to half of older adults and may lead to a reduction in quality of life. In a randomized clinical trial, Liu and colleagues show that electroacupuncture may be an effective treatment for stress urinary incontinence.   Stress urinary incontinence,
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The National Audit Office (NAO) published a report on July 27th regarding the inappropriate handling of unprocessed clinical correspondence, leading to a backlog, by the NHS Shared Business Services (NHS SBS).   The National Audit Office (NAO) in the United Kingdom published a report on July 27th regarding the inappropriate handling of unprocessed clinical correspondence
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Diabetic foot ulcers are one of the most common complications affecting diabetic patients. A recent review article outlines preventative measures that can decrease the odds of developing foot ulcers.   Diabetic foot ulcers, especially on the bottom of the foot, are a common problem in diabetics. Up to 26.1 million diabetic patients worldwide are estimated
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A study recently published in the American Journal of Clinical Nutrition explored various factors associated with inflammation in preschool children and women of reproductive age. It was found that recent illness and obesity were consistently associated with inflammation regardless of environment, while commonly measured demographic covariates, such as sex or socioeconomic status, were not.  
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PET scanning revealed elevated translocator protein in several regions comprising the neurocircuitry of Obsessive Compulsive Disorder (OCD), indicating a pathogenic role for microglia in the neuropathogenesis of OCD. Though several Hollywood stars have been diagnosed with OCD, no one is better remembered for suffering from this debilitating condition than Howard Hughes of ‘The Aviator’. Characterized
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Childhood obesity in the United States has long been a multifaceted disorder that health professionals have struggled to battle effectively. Strategies that if implemented at an early enough age and applied consistently afterwards can lessen obese children’s current health problems and the multitude that can appear later in adulthood such as cardiovascular disease. An article
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A recent study assessed the potential role of the fecal immunochemical test for colorectal cancer screening in at risk patients.   Colorectal cancer (CRC) develops in the colon or rectum, and it accounts for 10% of cancer-related mortality in western world1. Most colorectal cancer begins as a polyp then grow into advanced neoplasia(AN) and, ultimately,
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Researchers determine the effects of replacing glucose or sucrose with fructose on glucose, insulin, and triglyceride concentrations. When you think about eating healthier, what do you think about limiting in your diet? Sugar? Carbohydrates? Both?   Over the years, sugar has gained a bad reputation. The “bad” sugar that usually comes to mind is sucrose,
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  A new study finds that using soluble transferrin receptor (sTfR) concentrations to estimate nutritional iron deficiency anemia may be inaccurate as sTfR levels are affected in the presence of inflammation and malaria. The study proposes methods to adjust measured sTfR values when inflammation or malaria are present, so that these values reflect nutritional iron
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Cancer encompasses a range of diseases with varying mortality rates. A recent study has shown how cancer mortality rates have changed and influenced life expectancy over 30 years and have uncovered discrepancies in cancer control efforts between different populations.   Cancer is predicted to become the primary cause of global morbidity and mortality, surpassing cardiovascular
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Researchers investigated the effect of age and proton pump inhibitors on aspirin-associated bleeding in cardiovascular patients. The study found that use of proton pump inhibitors reduces the risk and severity of bleeding in patients 75 and older. Though antiplatelet therapies such as aspirin are routinely prescribed for the prevention of recurring cardiovascular events in older
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A recent study in JAMA Oncology compared the effectiveness of mammography alone vs. mammography in combination with MRI or ultrasonography in breast cancer screening. The results showed that combinatorial approaches could have a significant impact on detection rates and sensitivity for patients undergoing screening for recurrence.   Breast cancer screening is an indispensable practice in
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Viral infection with the hepatitis A has a low prevalence in Europe; however, a retrospective analysis found that while overall hepatitis A prevalence is decreasing, some regions still have a moderate to high risk of hepatitis A infection.   Hepatitis A is a disease caused by viral infection of the liver by the hepatitis A
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Inflammation and infection are known to affect measures of Iron deficiency (ID), and may lead to overestimation or underestimation of ID prevalence. Researchers investigated whether total body iron (TBI) values were subject to the same inaccuracies and found that TBI values underestimate the prevalence of ID in the presence of inflammation or infection and that
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Deep brain stimulation (DBS) of the thalamus is a well-known treatment for tremor related to Parkinson’s disease, but the research surrounding its efficacy with multiple sclerosis tremors remains inconclusive. DBS of two thalamic nuclei was found to significantly decrease tremor severity over the course of 6 months in individuals with multiple sclerosis tremors.   Multiple
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A new study validates the use of minimally invasive autopsies (MIAs) to accurately determine the cause of death in stillbirths and neonatal deaths. Since MIAs are less invasive, simpler, and more feasible, they could be an excellent tool to guide the development of preventative strategies to improve child survival in low-income, high-burden communities.   Each
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